Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication
Summary: The protein deacetylase SIRT1 (Sirtuin 1) regulates many cellular processes, including cell-cycle progression, DNA damage response, and metabolism.Although the centrosome is a key regulator of cell-cycle progression and genome stability, little is known concerning SIRT1 controlled centrosome-associated events.Here we report that the centro